HappyMutations:

This is part of the series Work-in-Progress, meaning that it will be indefinitely updated. cortico-striato-thalamo-cortical (CSTC) feedback loops • hyperactivation or hyperconnectivity of regions in the CSTC circuits -> OCD [doi:10.3389/fpsyt.2016.00078] • effects of hallucinogens and NMDA antagonists in humans may arise from elementary deficits of sensory information processing in the (CSTC) feedback loops [PMID:22033605] cortico-striato-pallido-thalamic (CSPT) circuitry • the CSPT modulates sensorimotor gating functions [PMID:22033605] • in animals, hallucinogens, amphetamines (including MDMA) and NMDA antagonists disrupt sensorimotor gating in rats by interacting with different components of the CSPT [PMID:22033605] The mesocortical pathway is a dopaminergic pathway that connects the ventral tegmentum to the prefrontal cortex The mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain. The pathway connects the ventral tegmental area in the midbrain, to the ventral striatum of the basal ganglia in the forebrain